Mammalian Cell Biology V: Signaling and Pharmacology

By the end of the course, students will have acquired a global vision of the molecular mechanisms involved in the reception and transmission of physiological and physico-chemical signals perceived by eukaryotic cells via receptors (GPCRs, channel receptors, Tyrosine kinase receptors). Students will be assessed on their ability to identify and interpret a signaling mechanism.

1A courses in Cell Biology, Pharmacology, or equivalent

Overview of the main intracellular signaling pathways and their activation mechanisms. Detailed description. Notions of signalosome and signal hub. Roles of protein kinases and phosphatases in cell signaling and gene expression regulation. Applications to pharmacology and diagnostics.