USP Intensification of bioproduction processes

Integration of cell culture technology solutions to industrial bioproduction problems.

 What are Single-Use technologies : What are they ? Who are the main suppliers in the market ?
Transition from the Stainless Steel installations to SUT : Why ? Cost comparison ? Advantages / Disadvantages ? Real case study
Single-Use and Sustainability : Are SUT greener than SS ? Utilities consumption comparison, carbon footprint etc...
Examples of SUT into processes : upstream / downstream / F&F / Hybrid systems
Challenges & Risks Associated with SUT : supply chain / E&L / Qualification & Validation / Bag integrity and sterile connections
Careers in the single-use world : example of positions at Single-use suppliers / at CDMO

FISE hours: 24 hours

Hourly volume of Contrat de Professionnalisation: 8 hours

Mammalian cells: perfusion - Integration of this culture method into the various phases of the process (cell banking, amplification, production) Microbial cells: high-density culture-Interest of this approach in heterologous protein production processes (dimensioning, cost, quality, productivity)-Process and/or product control (pH-stat, nutritional and metabolic aspects, DLS-SLS, flow cytometry).