Characterization and formulation of biomolecules 1

Identification of the characteristics required and the different levels of analysis used at each stage of the therapeutic protein's life cycle (RetD, in-process controls, quality control).

Analysis and formulation of therapeutic proteinsIntroduction: biological therapeutic molecules, industrial problems-Aggregation: a major physical instability of proteins in solution-Optimization of formulation to increase stability of biological products-Laboratory and automation platform for formulation of bio-therapeutics and vaccines-Kinetic modeling and stability prediction of biological products.General introduction to conventional protein delivery routes: advantages and disadvantagesPresentation of physiological barriers to be overcome, delivery technologies via these routes, constraints applied to proteins and solutions.