Toxicology basics and tools

Part One: Basics of Toxicology
Know the different fields of application of toxicology.
Describe the routes of intoxication (intoxication by inhalation, by the oral route, by the cutaneous route) and the fate of toxic substances in the body (Absorption, Distribution, Metabolism, Excretion). Know the main manifestations of adverse effects observed in organs or genetic material
Part Two: Tools for Food Toxicology
What tools can be used in Toxicology to identify and classify chemical hazards likely to have an impact on human health and/or the environment?

First-year chemistry, nutrition and toxicology courses

Part I: Basics of Toxicology


The science of toxicology
Principles of toxicology 2.1 Response profiles

2.2 Study of the ADME system

Mode of action of toxic compounds

3.1 Biological targets of toxic compounds
3.2 Mechanisms of action and signaling pathways of toxic compounds
3.3 Manifestations of toxicity at organ level

Action of toxic compounds at genome level (genotoxicity)

4.1 Mutagenesis process
4.2 Carcinogenesis process

Part II: Toxicology tools


Tools for identifying chemical hazards - Notion of Exposome


5.1 Notion of Predictive and Experimental Toxicology
5.2 Classification and categorization of chemical hazards (for health and the environment) according to EU regulation n°1272/2008 (CLP)
5.3 Origins and nature of the families of contaminants and chemical residues that contribute to the exposome.

Human nutrition and toxicology

Harper's Biochemistry, Muray/ Granner/ Mayes/ Rodwell, Edition de Boeck.
LubertStryer's Biochemistry, Médecines Sciences, Flammarion.
Microbiology, Prescott/ Harley/ Klein, Edition DeBoek
Biology by N. A. Campbell, Editions De Boek
Molecular Biology of the Cell, by Alberts B. et al, Editions Flammarion.
Picot A. and Louis J.M., 2006. Toxicochemistry. Notons de biologie et de chimie appliquée à la toxicologie. Tec et Doc, Lavoisier, Paris
Toxicolgie - Cours et sujets de synthèse. Under the direction of Xavier Coumoul. Edition Dunod (2017).
Traité de Toxicologie Générale. Springer Science and Business Media. (1999) - ISBN 2-287-59663.