Toxicology basics and tools

Part One: Basics of Toxicology

Know the different fields of application of toxicology.

Describe the routes of intoxication (inhalation, oral, dermal) and the fate of toxic substances in the body (absorption, distribution, metabolism, excretion). Know the main manifestations of adverse effects observed in organs or genetic material.

Part Two: Tools for Food Toxicology

What Toxicology tools can be used to identify and classify chemical hazards likely to have an impact on human health and/or the environment?

Part I: Basics of Toxicology
1. The science of toxicology
2. Principles of toxicology
2.1 Response profiles
2.2 Study of the ADME system

   3. Mode of action of toxic compounds
3.1 Biological targets of toxic compounds
3.2 Mechanisms of action and signaling pathways of toxic compounds
3.3 Manifestations of organ toxicity

    4. Action of toxic compounds on the genome (genotoxicity)
4.1 Mutagenesis process
4.2 Carcinogenesis process

Part II: Toxicology tools
Tools for identifying chemical hazards - Notion of Exposome

1. Notion of Predictive and Experimental Toxicology
2. Classification and categorization of chemical hazards (for health and the environment) according to EU regulation n°1272/2008 (CLP)
3. Origins and nature of families of contaminants and chemical residues that contribute to the exposome.

Harper's Biochemistry, Muray/ Granner/ Mayes/ Rodwell, Edition de Boeck.
LubertStryer's Biochemistry, Médecines Sciences, Flammarion.
Microbiology, Prescott/ Harley/ Klein, Edition DeBoek
Biology by N. A. Campbell, Editions De Boek
Molecular Biology of the Cell, by Alberts B. et al, Editions Flammarion.
Picot A. and Louis J.M., 2006. Toxicochemistry. Notons de biologie et de chimie appliquée à la toxicologie. Tec & Doc, Lavoisier, Paris
Toxicolgie - Cours et sujets de synthèse. Under the direction of Xavier Coumoul. Edition Dunod (2017).
Traité de Toxicologie Générale. Springer Science & Business Media. (1999) - ISBN 2-287-59663.