Dynamic organic chemistry

The aim of the course is to give students a better understanding of the reactivity of the main chemical functions, based on their chemical properties (acid/base, electrophile/nucleophile, hard/soft, oxidizing/reducing). Particular attention will be paid to reaction mechanisms and the reaction intermediates involved (radicals, carbocations and carbanions).

Target skills and knowledge:
- know the main organic chemistry functions, their physico-chemical properties and the main reactions associated with them
- correctly represent an organic molecule, taking into account its stereochemistry
- be able to determine the single or multiple reactivity of a molecule
- understand the reaction mechanisms involved and be able to describe them in accordance with writing conventions.
- predict the structure of a reaction product as a function of the reagents and conditions employed
- modify the functional properties of an organic molecule.

- Descriptive organic chemistry course on the basics of organic chemistry (BACOR) in S5

- S6 organic chemistry course (CORDY-1)

- Identify common functions in organic chemistry

- Know and use nomenclature rules (IUPAC and standard)

- Be able to represent a molecule using different representations (Cram, Newman and Fisher)

- Identify the electronic effects of a molecule (inductive and mesomeric)

-Distinguish between conformations and configurationsDistinguish between relative and absolute stereochemistry

- Determine the stereochemistry of an asymmetric center

- AE, SN, E, oxidation and reduction mechanisms

1 - Alcohols

1.1 - Presentation of alcohols

1.2 - Alcohol reactivity

1.2.1 - Alcohol nucleophilicity (SN, AN/E)

1.2.2 - Modification of the C-O bond (halogenation, dehydration, oxidation)

2 - Aromatic compounds

2.1 - Aromaticity and properties of aromatic compounds

2.2 - Reactivity of aromatic-benzene compounds (Addition reactions, Aromatic electrophilic substitutions, SN Ar, Benzyl position reactivity)

3 -Carbonyl derivatives

3.1 - Presentation

3.2 - Reactivity of aldehydes and ketones

3.2.1 - Nucleophilic additions to C=O (Reduction, acetalization, amine addition, organometallic addition)

3.2.2 - Reduction of carbonyl to methylene

3.2.3 - Oxidation of aldehydes

3.2.4 - Reactivity linked to the acidity of H in # carbonyl (halogenation, aldolysation, alkylation)

3.2.5 - Other examples of reactions involving carbanions (Knoevenagel, Darzens, Mannich and Wittig)

Molecular and Polymer Chemistry theme

- Cours de chimie organique (Paul Arnaud) - Dunod
- Traité de chimie organique (Peter Vollhardt and Neil Schore) - De boeck