Chemistry for health

This à la carte module aims to develop knowledge and skills in the fields of biosensor development as a diagnostic tool, and drug development: advanced multi-step synthesis of active ingredients, obtaining optically active compounds and their characterization, basic galenics and clinical testing will also be covered.
During this module, the learner will develop the following skills:

Obtaining or modifying the functional properties of an organic material
Choosing and implementing analytical methods on a molecular and macromolecular scale
Keeping a scientific, technological and competitive watch (collecting and analyzing articles and patents)
Searching, finding, analyzing and synthesizing information, analyze and synthesize information
Communicate orally and in writing
Integrate knowledge into a research problem, or an industrial or socio-economic sector in France or abroad
Have a very good level of oral and written English, enabling presentation of scientific advances and research work.

This module is ideal for the 3A CBI, LAI and NMT specializations.

Fundamentals of organic chemistry and chemical analysis CHIAP à la carte module for AGBs

This module is divided into two parts:
Biosensors. (16h) Neso Sojic (13.33h) , Philippe Veschambre (2.66h)
1. Introduction.
2. Molecular recognition and transduction.
3. Enzymatic biosensors.
3.1 Introduction and review of biological concepts
3.2 Immobilization of biomolecules on the transducer
3.3. Amperometric biosensors using enzymatic systems
3.4. Potentiometric biosensors
3.5. Multisensors
4.Optical biosensors.
5 Piezoelectric and micromechanical sensors.
6.Applications in the environment and food industry.
7.Case study- Biosensors
8.Enzymatic glucose sensors

Drugs.(33 h 40, 18 h Isabelle Gosse, 1h20 Sandra Pinet, Yohann Nicolas 8h40, Emilie Duffau 5 h20, Intervenant 1h20 )
1. Advanced multi-step synthesis (2 h 40 Isabelle Gosse, 1 h 20 Sandra Pinet, Yohann Nicolas and Isabelle Gosse 6 h project work info room)
1.1 Advanced reactivity
1.2 Protection deprotection
1.3 Retrosynthesis
2. Obtaining optically pure compounds (Isabelle Gosse 8 h)
2.1 Asymmetric synthesis
2.2 Purification of stereoisomers by chiral chromatography
2.3 Duplication
3. Characterization of active ingredients (2 hrs industrial speaker 2h40 Sandra Pinet, 1h20 Isabelle Gosse)
3.1 Mass spectrometry
3.2 2-dimensional NMR
3.3 Rotatory power and circular dichroism
4. Introduction to Galenics (Emilie Duffau Sanofi 4h)
5. Introduction to clinical testing (Emilie Duffau Sanofi 2h)

This section will be assessed on the basis of a knowledge test and the production of a poster in English describing a drug (synthesis, purification, characterization of the active ingredient, administration) or a biosensor. This poster will be presented in a 5-minute pitch to the whole group during a poster session in English. Poster session (4 h)

References

Chiral molecules, stereochemistry and properties A. Collet ed. Collet ed. EDP Sciences
Catalytic Asymmetric synthesis, third edition, I. Ojima, Wiley
Chemical Sensors and Biosensors: Fundamentals and Applications. -G. G. Ganica. Ed. Wiley
Food Biosensors. M. U. Ahmed, M. Zourob, E. Tamiya. RSC.
Smart Sensors for Environmental and Medical Applications. H. Hallil, H. Heidar. Wiley.