Assessment of Chemical Risks to Health, the Environment and Work

This à la carte module will enable you to deepen your toxicology skills and apply them to chemical risk assessment procedures. In particular, the analysis of hazards (mainly chemical hazards) and risk assessment procedures linked to their presence in food, cosmetics, pharmaceuticals, the environment and the workplace will be mastered.
This module is designed for students wishing to become engineers in an industrial sector where they will be confronted with exposure to chemicals in their research, development or production activities. This module is recommended for the INH, LAI, MIDD, CBI, NMT specializations.
On completion of this module, students should be able to:
- Describe and present the characteristics of the main chemical hazards with recognized effects on health, the environment or the workplace.
- Understand and master the procedures for identifying and characterizing emerging chemical hazards that may present a risk to human health, the balance of eco-systems or working conditions.
- Describe and master the methodologies for establishing toxicological reference values (threshold values) and determining regulatory threshold values.
- Understand the organization and operation of the various assessment agencies involved in risk assessment.
- Analyze and criticize opinions issued by risk assessment procedures.

S7 core toxicology course

Part I: Identification of chemical hazards to health, the environment and the workplace 13,33H - 10 CM (Claude Atgié - Philippe Veschambre - Stéphane Roca and/or Cédric Jaunat)

Presentation of regulatory criteria for classifying and categorizing hazards: 1 CM - Claude Atgié 1,33 H
Classification and categorization of chemical hazards 3 CM : Claude Atgié 2,66H - Stéphane Roca and/or Cédric Jaunat 1,33h
Study of the effects and mechanisms of action of chemical hazards 3CM : Philippe Vaschambre: 8h

Total part I: 13.33H
Part II: Methodology of a risk assessment procedure: 8CM + 2TD (Claude Atgié - Stephane Roca and/or Cédric Jaunat - Cyril Durou)

Hazard characterization (in silico, in vitro and in vivo approach): 4 CM + 1TD (Claude Atgié 2,66h +1,33 H (TD) - Cyril Durou (ECOTOX) 1,33H - Stéphane Roca and/or Cédric JAUNAT 1,33h)
Methodology for calculating health reference values : 4 CM (Claude Atgié: 2,66h - Cyril Durou: 1,33H - Stéphane Roca and/or Cédric Jaunat - 1,33H)
Methodology for calculating exposure or impregnation values: (2 CM + 1TD Claude Atgié 1.33H + 1.33H (TD) - Stéphane Rocca and/or Cédric J: 1.33h)

Total Part II: 15.96H
Part III: Organization and operation of the various national and international risk assessment agencies: 10,66H 8 CM

Presentation of the organization and operation of the structures involved in risk assessment: (2 CM Claude Atgié: 1,33H - Stéphane Roca and/or C Jaunat: 1,33H)
Presentation of the operation of the various alert structures and monitoring plans: (2 CM Claude Atgié: 2,66H)
Presentation of examples of risk assessment construction and progress (case studies.(4 CM Claude Atgié : 2,66H - Stéphane Roca and/or Cédric Joaunat - 1,33H - Cyril Durou - 1,33H)

Total part III : 9,64H

Part IV : Case studies in risk assessment 9,33H 2 CM + 5 TD (Claude Atgié 2.66H - Philippe Veschambre 1.33H - Stéphane Roca and/or Cédric JAUNAT 1 ?33 - Cyril Durou 1.33)

Elaboration and presentation of a risk assessment procedure (group work: report + defense) 5 TD (Free slots)
External speakers (Testimony on risk assessment) 2 CM - External speaker(s) (Conf.) : 2,66h

Total part IV : 9,31H

References

Picot A. and Louis J.M., 2006. Toxicochemistry. Notons de biologie et de chimie appliquée à la toxicologie. Tec et Doc, Lavoisier, Paris
Toxicolgie - Cours et sujets de synthè Sous la direction de Xavier Coumoul. Edition Dunod (2017).
Traité de Toxicologie Générale. Springer Science and Business Media. (1999) - ISBN 2-287-59663.
Chemical risk assessment of food. (2018)
Introduction à l'Ecotoxicologie. Tec et Doc. Lavoisier (2011)
Les Risques Chimiques Environnementaux. Méthodes d'Evaluation et Impacts sur les Organismes. Tec et Doc. Lavoisier (2011°.
Aide-mémoire du Risque Chimique. 3rd ed. Nichan Margosin. Dunod (2011)